Commentary A new model for rheumatoid arthritis?
نویسنده
چکیده
A chance observation has led to the development of a new murine model for inflammatory arthritis. Arthritis is induced, and transferred, by T-cell-dependent antibodies to glucose-6phosphate isomerase. This enzyme is expressed in all cells, and is detectable in serum. There are several similarities to rheumatoid arthritis (RA) in the murine disease. This elegant model raises several questions as to how and why a systemic response focuses inflammation so strongly on synovial joints. The model also re-introduces the possibility that antibodies to widely expressed self-proteins may play a role in the pathogenesis of RA.
منابع مشابه
Histopathological changes of the antigen-induced chronic arthritis in the knee joint of the rabbit
Background and Objectives: The cause and pathophysiology of rheumatoid arthritis has not been fully understood and an experimental model of this disease is essential for research on the problem. In this research study, establishment and histopathological changes of chronic arthritis due to intra-articula...
متن کاملSimultaneous Quadruple Joint Replacement (QJR) in Disabling Juvenile Rheumatoid Arthritis – a Case Report with Review of Literature
We wish to present a case of 47-year-old patient with Juvenile Rheumatoid Arthritis and ankylosis of both hips and bothknees treated by bilateral hip and knee arthroplasty in a single anaesthesia i.e. Quadruple joint replacement in singlesitting. He was back on his feet from his bed-ridden state within the fortnight following surgery. He has been followedup for four years and has been performin...
متن کاملEffect of Implementing Family-centered Empowerment Model on the Quality of Life in School-age Children Diagnosed with Rheumatoid Arthritis
Background: Rheumatoid arthritis is the most prevalent chronic rheumatologic disease of children. The quality of life (QOL) in these individuals is affected by physical pain, discomfort, treatment complications, and frequent absences from school leading to academic failure. No research similar to the present investigation was performed in this area. Aim: ...
متن کاملParadims of rheumatoid arthritis patients quality of life predictors based on path analysis of the Precede model
Introduction: Rheumatoid Arthritis (RA) can get a considerable impact on patients’ quality of life. Path analysis is an exact statistical method for determining the best causative model of variables. So, the aim of this paper is application of regression based path analysis for introduction of the best model of RA quality of life determinants, using Precede Model constructs. Methods: Thi...
متن کاملIs there an association between anti-TNF monoclonal antibody therapy in rheumatoid arthritis and risk of malignancy and serious infection? Commentary on the meta-analysis by Bongartz et al
A recent meta-analysis of randomized clinical trials reported by Bongartz and coworkers raised concerns about an increased rate of malignancy and serious infection in rheumatoid arthritis patients treated with anti-tumour necrosis factor monoclonal antibodies. This commentary discusses some of the methodological issues in their analysis and urges caution in interpreting the results.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015